MITOCHONDRIAL DYSFUNCTION: MECHANISMS AND ADVANCES IN THERAPY

Mitochondrial dysfunction: mechanisms and advances in therapy

SUPER ONCEA DAY Abstract Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression.Particularly, mitochondrial dysfunctions are identified in many common pathologies, including cardiovascular diseases, neurodegeneration, metabolic syndrome, and cancer.However,

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Multiplexed tat-Targeting CRISPR-Cas9 Protects T Cells from Acute HIV-1 Infection with Inhibition of Viral Escape

HIV-1 cure strategy by means of proviral knock-out using CRISPR-Cas9 has been hampered by the emergence of viral resistance against the targeting guide RNA (gRNA).Here, we proposed multiple, concentrated gRNA attacks against HIV-1 regulatory genes to block viral escape.The T cell line were transduced with single and multiple gRNAs targeting HIV-1 t

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